The response of neurons in the bed nucleus of the stria terminalis to serotonin: Implications for anxiety
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چکیده
منابع مشابه
The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety.
Substantial evidence has suggested that the activity of the bed nucleus of the stria terminalis (BNST) mediates many forms of anxiety-like behavior in human and non-human animals. These data have led many investigators to suggest that abnormal processing within this nucleus may underlie anxiety disorders in humans, and effective anxiety treatments may restore normal BNST functioning. Currently ...
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CGRP inhibits neurons of the bed nucleus of the stria terminalis: implications for the regulation of fear and anxiety.
The bed nucleus of the stria terminalis (BNST) is thought to generate anxiety-like states via its projections to autonomic and neuroendocrine regulatory structures of the brain. However, because most BNST cells are GABAergic, they are expected to inhibit target neurons. In contrast with this, infusion of calcitonin gene-related peptide (CGRP) into BNST was reported to potentiate anxiety while a...
متن کاملNeurons of the bed nucleus of the stria terminalis (BNST). Electrophysiological properties and their response to serotonin.
A descending pathway from the bed nucleus of the stria terminalis (BNST) to nuclei within the hypothalamus and brainstem has been implicated in the generation of anxiety.1 Drugs such as the 5-HT1A agonist, buspirone, and specific serotonin reuptake inhibitors (SSRIs), which are used to treat anxiety behaviors, act to modulate serotonin (5-HT) transmission.2 Hence, 5-HT may act as a neuromodulat...
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Background: The areas of the bed nucleus of the stria terminalis (BST) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST. Methods: Experiments were done in α-ch...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2009
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2009.05.013